Members
The activities of the NWSGC members will be jointly co-ordinated by Prof. Samar Hasnain (Daresbury) and Prof. John Helliwell (Manchester). A Project Board has been set up to oversee the build up of the facilites. A Joint Management Board with other genome related projects funded in the North West is envisaged. This is expected to comprise of the co-ordinators, the Vice-Chancellors of the four universities (Manchester, UMIST, Liverpool and John Moores) and the Research Directors of AstraZeneca and Daresbury Laboratory.
- Prof. S.S. HasnainDaresbury Laboratory
- Samar Hasnain has 25 years of experience in synchrotron radiation science. He has been working on the structure/function relationships of metalloproteins for more 20 years. His current research includes the investigation of metalloproteins involved in disease, the denitrification pathway of gram negative bacteria, cytochrome P450s and metalloproteins from Mycobacterium tuberculosis. Samar's research group use a variety of synchrotron based techniques including protein X-ray crystallography, X-ray absorption fine structure, small angle X-ray solution scattering and circular dichroism. The research group also uses electron spin resonance to investigate paramagnetic metal centres in proteins.
- Prof. J.R. Helliwell Chemistry Department, Manchester University
- John Helliwell has 25 years of experience in the field of protein crystallography. His research interests include synchrotron radiation, neutron diffraction, lectins, enzymes, structural chemistry/molecular biology/genomics, anomalous dispersion methods and Laue diffraction.
- Dr. H. Jhoti Astex Technology, Cambridge
- Harren Jhoti is a founder and chief scientific officer in Astex Technology. He has led the Structural Biology and Bioinformatics group at Glaxo Wellcome, specifically examining the application of crystal structure to drug discovery.
- Dr. I. Tickle Astex Technology, Cambridge
- Dr. S. Bailey Daresbury Laboratory
- Sue Bailey is an experienced protein crystallographer, involved in research on a number of metalloproteins involving molybdenum and tungsten metal centres (DMSO reductase) and novel iron centres (Prismane).
- Dr. J. Bella Medical School, Manchester University
- He is a lecturer in the Centre for Cell Matrix Research at Manchester's Medical School and is an experienced crystallographer. His current research includes extracellular matrix proteins and transmembrane cellular receptors. He is interested in understanding their role in cell communication, cell cycle regulation, and immune response control.
- Dr. A.G. Craig Tropical Medicine, Liverpool University
- He is a Senior Lecturer leading a research team at the Liverpool School of Tropical Medicine. He has a long standing history in malaria research and has been associated with the Malaria Genome Sequencing Project since its foundation. He is currently studying the molecular mechanisms involved in cytoadherence in order to design therapeutic inhibitors aimed at reducing severe disease.
- Dr. J.P. Derrick Biomolecular Sciences UMIST
- He is a lecturer in the Biomolecular Sciences Department at UMIST He heads a group that uses a wide range of biophysical techniques, including x-ray crystallography, to examine the structures and functions of protein involved in bacterial disease.
- Dr. C. Nave Daresbury Laboratory
- He has nearly 30 years of experience in crystallography and has worked at the SRS for 18 years. He has been involved in methods development for structural biology. He recently managed the development of the successful new protein crystallography beamline on a multipole wiggler at the SRS.
- Dr. R. Pauptit AstraZeneca
- He has 25 years of crystallographic experience and has led the AstraZeneca crystallography group for 8 years. With the number of medically important structure being addressed, he is interest in high throughput techniques. He initiated the northern regional protein crystallographic meetings and has consulted for several structural genomics initiatives.
- Prof. C.D. Reynolds Biomolecular Sciences, Liverpool JMU
- He has a background in chemistry and biochemistry, with over 30 years of experience in structural studies of biologically molecules. His interests include structure/function studies of proteins and x-ray crystallography. His laboratory is supported by the activities of Prof. J.P. Baldwin (small angle scattering and crystallography) and Dr. F.K.F. Korber (methods development).
- Dr. L. Tabernero Medical School, Manchester University
- She is a lecturer in the Division of Biochemistry at the University of Manchester's Medical School with several years of crystallographic experience. Her particularly interest is in reversible phosphorylation of proteins, the main regulatory mechanism in signal transduction pathways.
- Dr. D. Westhead Biological Sciences, University of Leeds
- Dr. David Westhead is a lecturer at the University of Leeds. His particular field of interest is in bioinformatics, and the prediction of protein structure and function from amino acid sequence.