Current Target List and Status
Below is a list of currently targeted proteins from the TB genome selected by members of the consortium.
| Investigator | Orf Name | Protein Function | Status January 2005 |
|---|---|---|---|
| Jordi Bella | Rv0171 | Part of mce1 operon | Ligation |
| Jordi Bella | Rv1963 | Putative transcriptional regulator | Ligation |
| Jordi Bella | Rv1942c | Hypothetical Protein | Sequencing |
| Jordi Bella | Rv2305 | Hypothetical Protein | Ligation |
| Jordi Bella | Rv3070 | CrcB Membrane Protein | Soluble |
| Mike Cianci | Rv3717 | Cell Biosynthesis | Targeted |
| Mike Cianci | Rv3919 | Cell Biosynthesis | Expressed |
| Mike Cianci | Rv2981c | D-Alanine-D-Alanine Ligase | Purification |
| Mike Cianci | Rv3712 | Cell Biosynthesis | Targeted |
| Mark Ellis | Rv2229c | Zn ribbon protein | Purification |
| Mark Ellis | Rv2711 | ideR, Fe dependent repressor | Purification |
| Mark Ellis | Rv3207c | Conserved hypothetical secreted protein | Expressed |
| Mark Ellis | Rv3836 | Acetylglutamtate kinase | Purification |
| Samar Hasnain | Rv2547 | Transcriptional Regulator CopG | Crystallising |
| Samar Hasnain | Rv0185 | Negative factor F (part) | Expression |
| Samar Hasnain | Rv2865 | Hypothetical metalloprotein | Purification |
| Samar Hasnain | Rv0359 | Probable integral membraneprotein | Expression |
| Samar Hasnain | Rv2776c | Putative Fe-S oxidoreductase | Purification |
| Samar Hasnain | Rv0247c | Succinate dehydrogenase | Purification |
| Samar Hasnain | Rv2718c | ATP binding protein | Purification |
| John Helliwell | Rv0510 | Hydroxymethylbilane synthase | Targeted |
| John Helliwell | Rv3307 | deoD, probable purine nucleoside phosphorylase | Targeted |
| Miroslav Papiz | Rv3910 | Possible membrane protein | Targeted |
| Miroslav Papiz | Rv0589 | mce2, cell invasion protein | Targeted |
| Miroslav Papiz | Rv0588 | Part of mce2 operon | Cloned II (Expression vector) |
| Miroslav Papiz | Rv2154c | ftsW, membrane protein (shape determination) | Cloned |
| Miroslav Papiz | Rv2938 | drrC, similar daunorubicin resistance transmembrane | Expressed |
| Miroslav Papiz | Rv3645 | Probable transmembrane protein | Targeted |
| Miroslav Papiz | Rv1273c | ABC transporter | Cloned |
| Miroslav Papiz | Rv2154c | Cloned | |
| Miroslav Papiz | Rv0924c | Targeted | |
| Lydia Tabernero | Rv0153c | Putative protein-tyrosine-phosphatase | Ligation |
| Lydia Tabernero | Rv0505c | serB, probable phosphoserine phosphatase | Ligation |
| Lydia Tabernero | Rv1967 | Part of mce3 operon | Expression |
| Lydia Tabernero | Rv2234 | ptpA, protein-tyrosine-phosphatase | Purification |
| Lydia Tabernero | Rv3042c | serB2, C-term similar to phosphoserine phosphatase | Purification |
| Lydia Tabernero | Rv3628 | ppa, probable inorganic pyrophosphatase | Purification |
| Lydia Tabernero | Rv3867 | Conserved hypothetical protein | Purification |
| Colin Reynolds | Rv3852 | Histone Like Protein | Targeted |
| Colin Reynolds | Rv2986c | Histone Like Protein | Expressed |
| Colin Reynolds | Rv1388 | Integration host factor | Expressed |
| Colin Reynolds | Rv1407 | Similar to other Fmu proteins | No PCR |